The study examined the influence of Open and Distance Education on access and quality of entrants to University Education. In particular the study examined the extent to which distance education has improved access to universities and whether improvement in access has led to decline in quality entrants in universities. It also sought to know whether differences existed in terms of quality of entrants between Dual and Uni -mode distance learning university. Three research questions were raised and three hypotheses formulated. Descriptive research design of the survey type was used. The population of the study comprised distance education students in the two public universities in Lagos state and National Open University of Nigeria, Lagos. A simple random sampling technique was used to select the sample. An instrument tagged Influence of Distance Education on Access and Quality Questionnaire (IDEAQ) was used to collect data from the subjects. The instruments were validated by colleagues in the area of measurement and evaluation. The reliability of the instruments was determined using Cronbach Alpha statistical tool. The researcher administered ten copies of the questionnaire on DLI students of University of Lagos. The result of the analysis is 0.77% showing that the instrument is reliable. Data collected for the study were analyzed using Chi-square (X2 ) and t-test statistical tools. The study revealed that Distance Education has influenced access and quality of entrants to universities in Lagos State. The study further reveals that Distance Education has improved access in both uni-mode and dual mode universities in Lagos State. This is a positive and strong effect on university Education through distance learning.